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Updated: Jul 11, 2026

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
[Mixed exocrine-endocrine gastric carcinoma: a rarity of little consequence?]
1Chirurgische Klinik, HELIOS Kliniken Schwerin, Schwerin. joerg_sauer@gmx.net
History And Admission Findings:
A 38-year-old woman was admitted for the diagnosis of joint pains. She had no gastrointestinal symptoms.
Investigations:
Barium contrast examination revealed a rigid gastric wall. Gastroscopy showed multifocal carcinoid (neuroendocrine) tumors, up to 3 mm in diameter, and a 2 cm tumor which had apparently not metastasised (as demonstrated by sonography and computed tomography), but had broken into the muscular layer.
Treatment And Course:
A partial gastrectomy and lymphadenectomies were performed. Histology showed a mixed exocrine-endocrine carcinoma with submucosal infiltration and lymph node metastases. The postoperative course was without complications.
Conclusion:
Neuroendocrine tumors are rare diseases of the stomach for which therapeutic options are surgical resection or endoscopic removal. Tumors up to 1 cm diameter and concomitant type A gastritis, multiple endocrine neoplasms with infiltration or Zollinger-Ellison syndrome are removed endoscopically. Bigger tumors or tumors that have infiltrated the muscular layer are managed by partial gastrectomy In our opinion radical surgery is required in all carcinoids larger than 1 cm and other neuroendocrine tumors.
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