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Related Experiment Video

Updated: Jul 11, 2026

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

Published on: September 18, 2011

Widespread spinal cord involvement in progressive supranuclear palsy.

Yasushi Iwasaki¹, Mari Yoshida, Yoshio Hashizume

¹Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. iwasaki@sc4.so-net.ne.jp

Neuropathology : Official Journal of the Japanese Society of Neuropathology

|September 29, 2007

Summary

Progressive supranuclear palsy (PSP) pathology affects the spinal cord, particularly the cervical segment. Spinal interneurons in the anterior horn and intermediate gray matter show significant damage.

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Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

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Published on: September 18, 2011

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

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Published on: March 4, 2014

Area of Science:

Neuropathology
Neurodegenerative Diseases
Spinal Cord Anatomy

Background:

Progressive supranuclear palsy (PSP) is a neurodegenerative disease with complex pathology.
Spinal cord involvement in PSP has not been fully elucidated.

Purpose of the Study:

To characterize the histopathologic features of spinal cord lesions in PSP.
To review the literature on spinal cord pathology in PSP.

Main Methods:

Histologic examination of spinal cord lesions in 10 PSP cases.
Gallyas-Braak (GB) staining and AT-8 tau immunostaining.
Correlation with medulla oblongata pathology.

Main Results:

Atrophy and myelin pallor observed in anterior and anterolateral funiculi (8/10 cases).
Posterior funiculus remained preserved.
Neuropil threads and tau-positive inclusions found in gray matter, particularly affecting spinal interneurons in the cervical segment.

Conclusions:

The spinal cord, especially the cervical segment, is consistently affected in PSP.
Spinal interneurons and their processes in the medial anterior horn and intermediate gray matter are severely damaged in PSP.