Related Experiment Video
Updated: Jul 11, 2026

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
Published on: May 4, 2020
[Effects of cholinergic antagonists in stress]
Abstract:
Effects of methacine, hexamethonium and their combinations with neostigmine on activity of B-lymphocytes in various phases of immune response and development of stress ulcers induced in animals were studied. The drugs were found to modulate B-lymphocyte activity for 28 days and longer. By a water-immersion stress model it was shown that methacin is effective not only as m-cholinolytic but also as an immunoprophylactic drug reducing destructive changes in gastric mucosa. Injection of methacin 30 min before stress (block of m-cholinoreceptors) or 14 days before stress (maximal increase of B cell activity) results in 3-4-fold inhibition of ulcerogenesis in gastric mucosa.
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