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Related Concept Videos

Subviral Agents01:29

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
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Amyloid Fibrils03:03

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Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Parkinson Disease ll: Pathophysiology01:24

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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...

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Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
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Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

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[Prion diseases].

J Smetana1, M Vacková, R Chlíbek

  • 1Univerzita obrany, Katedra epidemiologie Fakulty vojenského zdravotnictvi v Hradci Králové. smetana@pmfhk.cz

Epidemiologie, Mikrobiologie, Imunologie : Casopis Spolecnosti Pro Epidemiologii a Mikrobiologii Ceske Lekarske Spolecnosti J.E. Purkyne
|September 29, 2007
PubMed
Summary
This summary is machine-generated.

Prion diseases, including bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (nvCJD), require further research for better understanding and control. This article reviews current knowledge on their etiology, epidemiology, and management strategies.

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Last Updated: Jul 11, 2026

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Veterinary Medicine

Context:

  • Prion diseases encompass various long-recognized conditions.
  • Public awareness surged due to bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (nvCJD) outbreaks.
  • Despite advances, significant knowledge gaps persist regarding prion diseases.

Purpose:

  • To present the latest scientific understanding of prion disease etiology and epidemiology.
  • To focus on bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (nvCJD).
  • To outline control measures for these transmissible spongiform encephalopathies.

Summary:

  • Prion diseases, including BSE and nvCJD, are a group of neurological disorders.
  • Research continues to unravel the causative agents, pathogenesis, diagnosis, and treatment of these diseases.
  • This review synthesizes current knowledge on the origins, spread, and management of prion diseases, with emphasis on BSE and nvCJD.

Impact:

  • Enhances understanding of prion disease transmission and risk.
  • Informs public health policies and veterinary surveillance for BSE and nvCJD.
  • Highlights areas for future research in prion disease diagnostics and therapeutics.