Related Experiment Video
Updated: Jul 11, 2026
08:54
An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
Published on: July 20, 2014
Meta analysis: Cancer risk in Barrett's oesophagus
T Thomas1, K R Abrams, J S De Caestecker
1Digestive Diseases Centre, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK.
Alimentary Pharmacology & Therapeutics
|September 29, 2007
Summary
Cancer risk in Barrett's oesophagus shows no geographical variation. Short segment Barrett's oesophagus may have a reduced cancer risk, with an overall decreasing trend in cancer incidence over time.
Area of Science:
- Gastroenterology and Oncology
- Epidemiology
- Cancer Surveillance
Background:
- Barrett's oesophagus is a precancerous condition with variable reported cancer risks.
- Geographical variations in cancer incidence impact surveillance strategies.
Purpose of the Study:
- To conduct a meta-analysis to determine the incidence of oesophageal cancer in Barrett's oesophagus.
- To investigate geographical and temporal trends in cancer risk.
Main Methods:
- Systematic review of MEDLINE-indexed articles (1966-2004).
- Inclusion criteria: verified Barrett's oesophagus surveillance, documented follow-up, and cancer as outcome.
- Random effects meta-analysis model used, results expressed as mean with 95% confidence intervals.
Main Results:
- Overall cancer incidence in Barrett's oesophagus was 7 per 1000 person-years.
- No significant geographical variations in cancer incidence were detected across UK, USA, and Europe.
- Short segment Barrett's oesophagus showed a trend towards reduced cancer risk compared to conventional Barrett's oesophagus.
Conclusions:
- Barrett's oesophagus cancer risk does not vary geographically.
- A trend towards reduced cancer risk was observed in short segment Barrett's oesophagus.
- Evidence suggests a decreasing trend in cancer incidence over time.
Related Concept Videos
01:21Barrett Esophagus-I: Introduction
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
01:21Barrett Esophagus-II: Clinical Manifestations and Management
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
01:21Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
01:30Esophageal Strictures-I: Introduction
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...