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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

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Related Experiment Video

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Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications
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Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications

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Curcumin as "Curecumin": from kitchen to clinic.

Ajay Goel1, Ajaikumar B Kunnumakkara, Bharat B Aggarwal

  • 1Gastrointestinal Cancer Research Laboratory, Department of Internal Medicine, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX, United States.

Biochemical Pharmacology
|September 29, 2007
PubMed
Summary

Curcumin, the active compound in turmeric, shows broad therapeutic potential for inflammatory and chronic diseases. Clinical trials confirm its safety and efficacy, suggesting a promising role in medicine.

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Area of Science:

  • Pharmacology
  • Natural Product Chemistry
  • Molecular Biology

Background:

  • Turmeric (Curcuma longa) contains curcumin, a compound with a long history in Ayurvedic medicine.
  • Curcumin exhibits diverse biological activities, including anti-inflammatory, antiproliferative, and antioxidant properties.
  • Extensive research has elucidated curcumin's molecular mechanisms and therapeutic potential.

Purpose of the Study:

  • To review the multifaceted activities and therapeutic applications of curcumin.
  • To summarize preclinical and clinical evidence supporting curcumin's efficacy in various diseases.
  • To highlight curcumin's safety profile and potential as a therapeutic agent.

Main Methods:

  • Literature review of preclinical (cell culture, animal studies) and clinical trials.
  • Analysis of curcumin's molecular targets, including protein binding and gene expression modulation.
  • Evaluation of safety and efficacy data from human studies.

Main Results:

  • Curcumin modulates inflammatory pathways by inhibiting kinases and regulating transcription factors.
  • Preclinical studies indicate antiproliferative, anti-invasive, and antiangiogenic effects.
  • Clinical trials demonstrate safety and potential benefits in conditions like inflammatory bowel disease, cancer, and neurodegenerative diseases.

Conclusions:

  • Curcumin possesses significant therapeutic potential across a wide range of diseases.
  • Its safety and efficacy are supported by both preclinical and clinical evidence.
  • Curcumin is transitioning from a culinary spice to a clinically relevant therapeutic agent.