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Published on: January 28, 2020

Paraoxonase activity and coronary heart disease risk in healthy middle-aged males: the PRIME study

J A Troughton1, J V Woodside, J W G Yarnell

  • 1Faculty of Medicine, Queen's University Belfast, Belfast, Northern Ireland, UK.

Atherosclerosis
|September 29, 2007
PubMed

Insights

Neither paraoxonase activity nor PON55 genotype appears to influence coronary heart disease (CHD) risk in middle-aged males, according to the PRIME study. Further research is needed to understand CHD incidence variations.

Area of Science:

  • Cardiovascular Epidemiology
  • Biochemistry
  • Genetics

Background:

  • Coronary heart disease (CHD) incidence shows significant geographical variation, unexplained by traditional risk factors.
  • The Prospective Epidemiological Study of Myocardial Infarction (PRIME) investigated novel risk factors in populations with differing CHD rates.

Purpose of the Study:

  • To investigate the association between paraoxonase activity and CHD risk.
  • To examine the relationship between the PON55 LL genotype and CHD risk.

Main Methods:

  • Paraoxonase activity was measured in male myocardial infarction cases and matched controls.
  • Genotyping for the PON55 polymorphism was performed on available DNA samples from cases and controls.

Main Results:

  • No significant difference in paraoxonase activity was observed between CHD cases and controls.
  • Paraoxonase activity levels did not correlate with CHD risk, even after adjusting for classical risk factors.
  • The PON55 genotype (LL, LM, MM) showed no significant association with CHD risk.

Conclusions:

  • Paraoxonase activity is not associated with CHD risk in middle-aged males within the PRIME study cohort.
  • The PON55 genotype does not appear to be a significant risk factor for CHD in this population.
Abstract

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