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Ultrasound-driven microbubble oscillation and translation within small phantom vessels
Hairong Zheng1, Paul A Dayton, Charles Caskey
1Department of Biomedical Engineering, University of California, Davis, CA 95616, USA.
Ultrasound in Medicine & Biology
|September 29, 2007
Summary
Ultrasound radiation force manipulates microbubbles in small vessels, but oscillation is reduced. Pulse trains effectively displace microbubbles to vessel walls for enhanced ultrasound imaging and drug delivery applications.
Area of Science:
- Biomedical Engineering
- Acoustic Physics
- Nanotechnology
Background:
- Ultrasound radiation force is explored for microbubble manipulation in blood vessels.
- Enhanced ultrasonic molecular imaging and drug delivery efficiency are key goals.
- Microbubble oscillation is reportedly diminished in small blood vessels.
Purpose of the Study:
- Investigate microbubble oscillation and translation within 12 micrometer vessels.
- Quantify microbubble displacement under ultrasound pulses.
- Compare experimental findings with theoretical models.
Main Methods:
- High-speed photography to observe microbubbles in 12 micrometer tubes.
- Application of single ultrasound pulses (0.1-1 MPa) and pulse trains.
- Modeling of coupled oscillation and translation using modified Rayleigh-Plesset equations.
Main Results:
- Microbubbles in 12 micrometer tubes translated 5-10 times less than in 200 micrometer tubes.
- High pulse repetition frequency pulse trains displaced bubbles to vessel walls within ~1 second.
- Theoretical modeling agreed with experimental observations for larger displacements.
Conclusions:
- Microbubble dynamics are significantly affected by vessel confinement.
- Ultrasound pulse trains show promise for targeted microbubble manipulation in clinical settings.
- Findings advance understanding of bubble dynamics in constrained environments for ultrasound applications.
