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Aging and sex differences in striatal dopaminergic function.

J L McDermott1, D E Dluzen

  • 1Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, P.O. Box 95, Rootstown, OH 44272-0095, USA.

Neuroscience
|September 29, 2007
PubMed
Summary
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Age significantly alters dopamine (DA) and DOPAC responses in mouse striatal tissue, with female mice exhibiting more pronounced age-related changes than males. These shifts may correlate with hormonal fluctuations across the lifespan.

Area of Science:

  • Neuroscience
  • Neuroendocrinology
  • Aging Research

Background:

  • Dopaminergic (DA) system function is crucial for motor control and reward.
  • Age-related changes in neurotransmitter systems can impact neurological health.
  • Sex differences in neurobiology are increasingly recognized, particularly concerning hormonal influences.

Purpose of the Study:

  • To compare age- and sex-dependent alterations in striatal dopamine and DOPAC release.
  • To investigate the impact of aging on potassium- and amphetamine-stimulated DA and DOPAC responses in male and female mice.
  • To explore potential correlations between estrous cycle status and neurochemical changes in aging female mice.

Main Methods:

  • Superfused striatal tissue from female and male mice aged 2, 6, 18, and 24 months.

Related Experiment Videos

  • Stimulation of dopamine (DA) and 3,4-dihydroxy phenylacetic acid (DOPAC) release using potassium (30 mM) and amphetamine (10 microM).
  • Comparison of DA and DOPAC output across different age groups and sexes.

    • Main Results:

    • Female mice showed significant decreases in potassium-stimulated DA at 18 months and increases at 24 months, unlike males who only showed an increase at 24 months.
    • Amphetamine-stimulated DA responses decreased in 18-month-old females and increased in 24-month-old females, while males showed decreases at 6 and 18 months.
    • Female 24-month-old mice had higher amphetamine-stimulated DA responses than males; DOPAC response patterns mirrored DA in males but not females.

    Conclusions:

    • Striatal dopaminergic function is differentially affected by age in male and female mice.
    • Female mice exhibit more extreme age-related changes in striatal DA responsiveness, potentially linked to the presence or absence of estrous cycles and gonadal steroid hormones.
    • Age-related neurochemical changes in the striatum highlight significant sex differences and hormonal influences on brain aging.