Related Experiment Video
Updated: Jul 11, 2026
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Tissue effects after stereotactic body radiotherapy using cyberknife for patients with abdominal malignancies
J S Cupp1, A C Koong, G A Fisher
1Department of Pathology, Stanford University Medical Center, Stanford, CA, USA.
Aims:
To report the tissue effects of treatment with single fraction stereotactic body radiotherapy (SBRT) using Cyberknife on malignant tumours of the abdomen and adjacent normal organs.
Materials And Methods:
The data from four autopsies with unresectable pancreatic carcinoma and one lymph node excision from a case of recurrent neuroblastoma were reviewed for radiation-related tissue effects within the primary cancer and the normal organs within the radiation field.
Results:
Cases of unresectable pancreatic carcinoma consistently showed radiation-induced changes in both the primary tumour and the adjacent, non-malignant colorectal tissue. An additional case of lymph nodes exposed to stereotactic radiation showed typical radiation-related changes, including lymphocyte depletion and capsular fibrosis.
Conclusions:
A myriad of radiation-related tissue effects are seen after SBRT with Cyberknife. The changes parallel those reported after conventionally fractionated radiotherapy and suggest that the pathophysiological mechanisms of radiation-induced normal tissue damage are similar for biologically equivalent single and fractionated doses of radiotherapy.
