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Cluster headache attacks and multiple sclerosis

Salvatore Gentile1, Margherita Ferrero, Giovanna Vaula

  • 1Neurology II - Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15, I-10126, Torino, Italy. sgentile@molinette.piemonte.it

The Journal of Headache and Pain
|September 29, 2007
PubMed

Insights

Cluster headache attacks in a patient resolved after methylprednisolone treatment for multiple sclerosis (MS). This case highlights the importance of neuroimaging for cluster headache patients to rule out structural lesions.

Area of Science:

  • Neurology
  • Neuroimmunology

Background:

  • Cluster headache is a primary headache disorder.
  • Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.

Observation:

  • A patient presented with typical cluster headache attacks.
  • The patient was concurrently diagnosed with multiple sclerosis.
  • Headache attacks resolved following intravenous methylprednisolone treatment.

Findings:

  • Magnetic Resonance (MR) imaging revealed a pontine demyelinating lesion.
  • The lesion involved the trigeminal nerve root inlet area ipsilateral to the headache pain.
  • This case represents a rare association between cluster headache and MS.

Implications:

  • The co-occurrence of cluster headache and MS is infrequently reported.
  • This case underscores the utility of neuroimaging in evaluating cluster headache.
  • Neuroimaging can help exclude structural lesions in patients with cluster headache.

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