Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human stem cells for CNS repair.

Rike Zietlow1, Emma L Lane, Stephen B Dunnett

  • 1Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, CF10 3US, UK. zietlowr@cf.ac.uk

Cell and Tissue Research
|September 29, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pridopidine in early-stage manifest Huntington's disease: a phase 3 trial.

Nature medicine·2025
Same author

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging.

Scientific reports·2025
Same author

Imaging of human stem cell-derived dopamine grafts correlates with behavioural recovery and reveals microstructural brain changes.

Neurobiology of disease·2025
Same author

Neurotrophic factors for Parkinson's disease: Current status, progress, and remaining questions. Conclusions from a 2023 workshop.

Journal of Parkinson's disease·2025
Same author

Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Graft ischemia post cell transplantation to the brain: Glucose deprivation as the primary driver of rapid cell death.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2025
Same journal

Correction to: Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Deletion of CEACAM1 does not affect retinal and choroidal morphology or transcriptome.

Cell and tissue research·2026
Same journal

Cardiac α2δ1 C-terminal contributes to left atrial hypertrophy in chronic ischemic heart failure, in association with changes in membrane GluN1 and p-CAMKII/p-HDAC4 signaling.

Cell and tissue research·2026
Same journal

Gill ionocytes of the Lake Magadi tilapia (Oreochromis Alcolapia grahami), an extremophilic teleost native to a highly alkaline environment.

Cell and tissue research·2026
Same journal

Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Effects of gestational protein restriction on autophagy dynamics during odontogenesis.

Cell and tissue research·2026
See all related articles

Human stem cell therapy shows promise for central nervous system (CNS) repair, but current treatments offer moderate effects. Further research is crucial to understand the biological principles for effective CNS regeneration.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cell Biology

Background:

  • The central nervous system (CNS) exhibits limited self-repair capabilities compared to peripheral tissues.
  • Adult brains contain stem cells, but their regenerative potential after disease or injury is minimal.
  • Stem cell transplantation is a developing therapeutic strategy for neurodegenerative diseases and acute CNS injuries.

Purpose of the Study:

  • To review the suitability of diverse human stem cell sources for treating CNS conditions.
  • To evaluate stem cell potential for neurodegenerative diseases (e.g., Parkinson's, Huntington's, multiple sclerosis) and acute injuries (e.g., stroke, spinal cord injury).

Main Methods:

  • Review of current scientific literature on human stem cell sources and their application in CNS repair.

Related Experiment Videos

  • Analysis of preclinical and early clinical trial data for stem cell transplantation in CNS disorders.

    • Main Results:

    • Human stem cell transplantation is progressing towards clinical application, with initial trials using autologous mesenchymal stem cells.
    • Observed therapeutic effects are currently moderate and do not yet meet the full expectations for replacing degenerated cells in the CNS.
    • Significant challenges remain in understanding the practicalities and biological mechanisms of stem cell therapy for CNS repair.

    Conclusions:

    • While stem cell therapy holds potential for CNS repair, current outcomes are modest.
    • Extensive research in experimental models is necessary to optimize stem cell use and elucidate underlying biological principles for successful CNS regeneration.