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Updated: Jul 11, 2026
07:43
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Endodermal sinus tumor of the paranasal sinuses
Anupam Mishra1, Adel K El-Naggar, Franco DeMonte
1Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Head & Neck
|September 29, 2007
Summary
A rare endodermal sinus tumor (EST) of the paranasal sinus was treated with chemotherapy, craniofacial resection, and radiation therapy. The patient achieved a tumor-free status at 1-year follow-up.
Area of Science:
- Oncology
- Pathology
- Neurosurgery
Background:
- Endodermal sinus tumor (EST) of the paranasal sinus is exceptionally rare.
- This case involves a 59-year-old male presenting with nasal obstruction.
Observation:
- High-resolution MRI revealed a nasoethmoid mass with extensive sinus and intracranial extension.
- Histopathology demonstrated a biphasic tumor with poorly differentiated carcinoma and EST components.
- Immunohistochemistry confirmed tumor markers, including alpha-fetoprotein.
Findings:
- Neoadjuvant chemotherapy (ifosfamide, paclitaxel, cisplatin) achieved partial tumor regression.
- A radical anterior craniofacial resection was performed due to skull base involvement.
- Adjuvant intensity-modulated radiation therapy was administered post-surgery.
Implications:
- The case highlights the challenges in managing rare sinonasal tumors.
- Multimodal treatment, including surgery and adjuvant therapies, can lead to favorable outcomes.
- Further research is needed to establish standardized treatment protocols for sinonasal EST.
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