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Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Obesity

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Related Experiment Video

Updated: Jul 11, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

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Published on: February 2, 2017

Upper and lower limb functionality: are these compromised in obese children?

Diane L Riddiford-Harland1, Julie R Steele, Louise A Baur

  • 1Department of Biomedical Science, Biomechanics Research Laboratory, University of Wollongong, NSW 2522, Australia. dianer@uow.edu.au

International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity
|September 29, 2007
PubMed
Summary
This summary is machine-generated.

Obese children show stronger upper body strength but impaired lower body power and chair rising ability. Their increased body mass hinders movement against gravity, impacting daily functional tasks.

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Area of Science:

  • Pediatric obesity research
  • Biomechanics and functional strength assessment
  • Childhood physical development

Background:

  • Childhood obesity is a growing public health concern.
  • Obesity can significantly impact a child's physical capabilities and functional performance.
  • Understanding the specific effects on limb strength and power is crucial for targeted interventions.

Purpose of the Study:

  • To investigate the impact of obesity on upper and lower limb functional strength and power in children.
  • To assess if obese children have compromised ability in performing daily activities like rising from a chair.
  • To compare functional capabilities between obese and non-obese children.

Main Methods:

  • Assessed upper and lower limb strength and power in 43 obese and 43 non-obese children (aged 8.4 years) using field-based tests.
  • Included arm push/pull, basketball throw, vertical jump (VJ), and standing long jump (SLJ).
  • Quantified chair rising ability in a subset of 13 obese and 13 non-obese children.

Main Results:

  • Obese children exhibited significantly greater upper limb push and pull strength compared to non-obese peers.
  • However, obese children showed significantly impaired vertical jump and standing long jump performance.
  • Obese children took significantly longer to complete the chair rising task, indicating reduced functional lower limb strength.

Conclusions:

  • Young obese children experience impeded lower limb functionality.
  • Increased body mass in obese children negatively affects their ability to move against gravity.
  • Obesity compromises essential functional movements crucial for daily activities.