Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Calmodulin-dependent Signaling

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...

Interactions Between Signaling Pathways

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

Autocrine Signaling

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...

Autocrine Signaling

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Changes of neuromuscular transmission in smooth muscles of rats bladder with experimental diabetes].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)·2014

Same author

[Urothelium-dependent modulation of urinary bladder smooth muscle contractions by menthol].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)·2012

Same author

[Comparative effects of menthol and icilin on the induced contraction of the smooth muscles of the vas deferens of normal and castrated rats].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)·2011

Same author

[Changes in calcium-dependent potassium channels of isolated smooth muscle cells of the bladder in rats with experimental diabetes].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)·2011

Same author

[Effects of N-stearoyl- and N-oleoylethanolamine on cardiac voltage-dependent sodium channels].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)·2011

Same author

[Modulation of the smooth muscle contractions of the rat vas deferens by TRPM8 channel agonist menthol].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)·2010

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

[Calcium signaling in carcinogenesis].

Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994)

|October 2, 2007

Summary

Cancer cell growth involves abnormal calcium (Ca2+) signaling. This review explores how altered Ca2+ distribution and handling proteins contribute to uncontrolled cell proliferation and reduced apoptosis in cancer, potentially revealing new treatment targets.

Area of Science:

Cell Biology
Biochemistry
Oncology

Context:

Cancer development involves dysregulated cell proliferation and apoptosis.
Calcium ions (Ca2+) are critical signaling molecules in cellular processes.
Understanding calcium's role in cancer is crucial for therapeutic advancements.

Purpose:

To review alterations in calcium distribution across cellular compartments during cancer progression.
To identify key Ca2+-handling proteins involved in malignant transformation.
To analyze the impact of altered calcium signaling on cellular responses in cancer.

Summary:

Malignant transformation is characterized by excessive cell proliferation and impaired apoptosis, processes heavily influenced by calcium ions (Ca2+).
This review examines shifts in Ca2+ distribution (extracellular, cytoplasmic, ER, mitochondrial) and the Ca2+-handling proteins involved during the transition from normal to cancerous cells.

More Related Videos

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts

Published on: October 25, 2011

Related Experiment Videos

Last Updated: Jul 11, 2026

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts

Published on: October 25, 2011

Changes in the spatial and temporal dynamics of Ca2+ signals are analyzed in relation to regulating cellular responses in cancer.

Impact:

Elucidating molecular events in calcium dysregulation can lead to novel cancer treatment strategies.
Provides insights into calcium signaling pathways as potential therapeutic targets for various cancers.
Enhances understanding of fundamental cell biology relevant to pathological conditions.