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Related Experiment Videos

Ascorbic acid concentration in amniotic fluid in late pregnancy.

B Barrett1, E Gunter, J Jenkins

  • 1Department of Maternal and Child Health, Grady Memorial Hospital, Atlanta, Ga.

Biology of the Neonate
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Smoking during pregnancy significantly lowers ascorbic acid (vitamin C) levels in both maternal blood and amniotic fluid. Amniotic fluid vitamin C reflects maternal status, with smoking having a pronounced effect.

Area of Science:

  • Obstetrics and Gynecology
  • Nutritional Science
  • Biochemistry

Background:

  • Ascorbic acid (vitamin C) is crucial for fetal development and maternal health.
  • Smoking during pregnancy is associated with various adverse outcomes.
  • The impact of smoking on ascorbic acid levels in amniotic fluid is not fully understood.

Purpose of the Study:

  • To investigate the relationship between smoking and ascorbic acid concentrations in maternal serum and amniotic fluid.
  • To determine if amniotic fluid ascorbic acid levels reflect maternal status.
  • To assess the influence of smoking on ascorbic acid levels in different maternal compartments.

Main Methods:

  • Collected amniotic fluid and venous blood specimens from 34 pregnant women.
  • Analyzed specimens for ascorbic acid concentration.

Related Experiment Videos

  • Compared ascorbic acid levels between smoking and non-smoking pregnant women.

    • Main Results:

    • Smokers had significantly lower serum and amniotic fluid ascorbic acid levels compared to non-smokers.
    • Mean amniotic ascorbic acid in smokers was less than 50% of non-smokers.
    • Smoking had a greater impact on decreasing amniotic fluid ascorbic acid than serum levels.
    • No significant difference in ascorbic acid levels was observed concerning premature rupture of membranes.

    Conclusions:

    • Amniotic fluid ascorbic acid concentration serves as a reliable indicator of maternal ascorbic acid status.
    • Smoking during pregnancy substantially depletes ascorbic acid levels in both maternal serum and amniotic fluid.
    • The effect of smoking on reducing ascorbic acid is more pronounced in amniotic fluid than in maternal serum.