Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chemotaxis and Direction of Cell Migration

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...

Chemotaxis in E. coli

Chemotaxis in E. coli

Chemotaxis in Escherichia coli is a sensory-driven motility mechanism that enables bacteria to navigate chemical gradients, moving toward beneficial environments while avoiding harmful conditions. This process relies on a signal transduction system integrating external chemical cues with flagellar motor control.Chemoreceptors and Signal DetectionE. coli detects chemical gradients through methyl-accepting chemotaxis proteins (MCPs), which are membrane-bound chemoreceptors that sense attractants...

Actin Polymerization and Cell Motility

Actin Polymerization and Cell Motility

Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate.

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...

Cytoskeletal Coordination in Cell Migration

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...

Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Moderately ectopic expressing NLP27 in potato confers high disease resistance without yield penalty.

Plant cell reports·2026

Same author

Mean First Passage Times of Higher-Dimensional Velocity Jump Processes.

Physical review letters·2026

Same author

Anti-fatigue mechanism of <i>Dendrobium officinale</i> pseudobulbs from different growth durations against chronic fatigue syndrome in mice and analysis of their active chemical components.

Frontiers in cell and developmental biology·2026

Same author

A novel internal reference microorganism-based method reveals wild-enriched <i>Penicillium</i> for enhancing growth and disease resistance in <i>Fritillaria thunbergii</i>.

Frontiers in microbiology·2026

Same author

Calcium signalling in glioblastoma networks of different topologies and possible treatments.

Mathematical biosciences·2026

Same author

The transgenic Vip3A poplar plant confers high resistance against Hyphantria cunea Drury.

Transgenic research·2026

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

Classical solutions and pattern formation for a volume filling chemotaxis model.

Zhian Wang¹, Thomas Hillen

¹Department of Mathematical and Statistical Science, University of Alberta, Edmonton Alberta T6G 2G1, Canada.

Chaos (Woodbury, N.Y.)

|October 2, 2007

Summary

This study proves classical solutions exist for a generalized cell movement model with volume filling effects. Cell growth drives pattern emergence, while merging patterns occur without cell growth.

More Related Videos

Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior

Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior

Published on: January 31, 2020

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

Related Experiment Videos

Last Updated: Jul 11, 2026

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior

Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior

Published on: January 31, 2020

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

Area of Science:

Mathematical biology
Cellular dynamics
Pattern formation

Background:

Chemotaxis models describe cell movement in response to chemical signals.
Volume filling effects are crucial in dense cell populations.
Understanding pattern formation is key to cellular organization.

Purpose of the Study:

To establish global existence of classical solutions for a generalized chemotaxis model.
To analyze spatial pattern formation and bifurcations.
To investigate the role of cell kinetics and growth in pattern dynamics.

Main Methods:

Mathematical analysis to establish existence of solutions.
Nonlinear analysis to determine conditions for pattern formation.
Numerical simulations to visualize complex dynamics.

Main Results:

Global existence of classical solutions is proven.
Conditions for spatial pattern formation are identified.
Numerical simulations reveal merging patterns (zero cell kinetics) and emerging patterns (nonzero cell kinetics).

Conclusions:

Cell growth is identified as the mechanism for pattern emergence.
The model captures complex behaviors like pattern merging and formation.