Related Experiment Video
Updated: Jul 11, 2026

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
Closure of a muscular ventricular septal defect using the Amplatzer ventricular occluder
Majid Dehghani1, Mohammad-Bagher Sharifkazemi, Amir Aslani
1Catheterization and Cardiovascular Intervention Unit, Shaheed Lavasani Hospital, Tehran, Iran.
Insights
Transcatheter closure using the Amplatzer device offers a safe and effective alternative to surgical repair for ventricular septal defects. This minimally invasive technique demonstrates high success rates and fewer complications for patients.
Area of Science:
- Cardiology
- Interventional Cardiology
- Pediatric Cardiology
Background:
- Surgical closure of ventricular septal defects (VSDs) carries risks including cardiopulmonary bypass complications and potential heart block.
- Minimally invasive transcatheter occlusion is increasingly preferred over surgical repair for VSD closure.
- The Amplatzer muscular VSD occluder represents an advanced device for transcatheter VSD treatment.
Observation:
- An 18-year-old patient presented with a ventricular septal defect.
- The patient underwent transcatheter closure of the VSD.
- The Amplatzer muscular VSD occluder was utilized for the procedure.
Findings:
- Transcatheter closure of the VSD was successfully performed using the Amplatzer occluder.
- The Amplatzer device demonstrated safety and a high success rate in this patient.
- This represents the first reported use of the Amplatzer VSD occluder in Iran.
Implications:
- Transcatheter VSD closure with the Amplatzer device is a viable and effective treatment option.
- This technique may reduce the risks associated with traditional surgical VSD repair.
- Expanding the use of the Amplatzer occluder can improve VSD management in Iran and beyond.
Abstract:
Surgical closure of ventricular septal defect is safe, however, the inherent risks associated with cardiopulmonary bypass and the potential early and late postsurgical complications including complete heart block, arrhythmias, postpericardiotomy syndrome, and rare deaths have led physicians to prefer transcatheter occlusion technique for closure of such defects. The use of Amplatzer muscular ventricular septal defect occluder is safe and associated with a higher success rate than other previously used devices. For the first time in Iran, we report an 18-year-old patient with ventricular septal defect who was successfully treated using the Amplatzer ventricular septal defect occluder.
Related Concept Videos
Mitral Stenosis III: Medical Management
Mitral Stenosis I: Introduction
Aortic Regurgitation III: Medical Management

