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Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
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Related Experiment Video

Updated: Jul 11, 2026

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

Antigen receptor V-segment usage in mucosal T cells.

A G Edwards¹, A R Weale, A J Denny

¹Department of Veterinary Pathology, Infection and Immunology, University of Bristol, Bristol, UK. dr_ag_edwards@yahoo.com

|October 2, 2007

Summary

The T-cell receptor repertoire in the rat intestine is surprisingly diverse, even between individual rats and different gut segments. This suggests subtle environmental factors and antigen exposure shape immune cell populations.

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Last Updated: Jul 11, 2026

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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

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Published on: January 12, 2021

Area of Science:

Immunology
Gastroenterology
Molecular Biology

Background:

The established model describes naive T cells recirculating through lymphoid tissues, while effector/memory T cells migrate to the intestinal mucosa.
Understanding the T-cell receptor (TCR) repertoire within the intestine is crucial for comprehending immune responses in this site.

Purpose of the Study:

To investigate and characterize the T-cell receptor repertoire diversity within the rat small intestine and associated lymphoid tissues.
To compare the TCR repertoire between different intestinal segments (proximal vs. distal) and systemic lymphoid organs (spleen, mesenteric lymph nodes).

Main Methods:

Spectratyping was employed to analyze the TCR repertoire in intestinal tissues, mesenteric lymph nodes, and spleen from PVG rats.
Automated sequencing and hierarchical cluster analysis were used for statistical evaluation of the spectratyping products.

Main Results:

A restricted T-cell repertoire was observed in the small intestine compared to mesenteric lymph nodes and spleen.
Significant repertoire variations were found between individual, genetically identical rats under identical conditions.
Marked differences in TCR repertoire were also identified between the proximal and distal segments of the small intestine within individual rats.

Conclusions:

The findings challenge the homogeneity expected in inbred animals, indicating significant plasticity in the intestinal immune cell repertoire.
Subtle environmental influences and antigen load likely drive divergence in TCR repertoires over time.
Selective recruitment or retention of antigen-driven T cell clones contributes to the distinct repertoires observed in different intestinal segments.