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Conjugated linoleic acid (CLA) and obesity
Manuela-Belén Silveira1, Raffaele Carraro, Susana Monereo
1Servicio de Endocrinología y Nutrición, Hospital Universitario de La Princesa, Diego de León, 62. 28006 Madrid, Spain. belensilveira@telefonica.net
Public Health Nutrition
|November 21, 2007
Summary
Conjugated linoleic acid (CLA) shows no conclusive evidence of effectiveness in humans for body composition changes. Further research is needed to understand its mechanisms and potential effects.
Area of Science:
- Nutritional Science
- Biochemistry
- Human Physiology
Background:
- Conjugated linoleic acid (CLA) encompasses various isomers of linoleic acid (LA).
- The trans-10,cis-12 CLA isomer demonstrated effects on adiposity and lean mass in animal studies.
- Dietary CLA in humans predominantly consists of the cis-9,trans-11 isomer (rumenic acid).
Purpose of the Study:
- To review animal and human studies on CLA effects on body composition.
- To explore potential mechanisms underlying CLA's influence on metabolism and weight.
- To provide an updated perspective on CLA research.
Main Methods:
- Comprehensive literature review of existing studies.
- Analysis of research data from animal models and human trials.
- Synthesis of findings on CLA isomer efficacy and safety.
Main Results:
- Human studies have not shown significant effects of CLA isomers on body weight or composition.
- Some research indicates a potential trend towards reduced body fat and increased lean mass.
- Concerns exist regarding potential adverse effects of trans-10,cis-12 CLA on metabolic health.
Conclusions:
- The effectiveness of conjugated linoleic acid (CLA) in humans remains inconclusive.
- More research is required to ascertain the benefits and risks of CLA supplementation.
- Understanding the specific mechanisms of different CLA isomers is crucial.
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