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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Death receptors and apoptosis

Emmanuel Contassot1, Olivier Gaide, Lars E French

  • 1Department of Dermatology, Zurich University Hospital, Gloriastrasse 31, 8091 Zürich, Switzerland.

Dermatologic Clinics
|October 2, 2007
PubMed

Insights

Tumor necrosis factor death receptors are vital for skin health and trigger apoptosis. Their dysregulation is linked to skin diseases like toxic epidermal necrolysis, graft versus host disease, and skin cancer.

Area of Science:

  • Dermatology
  • Immunology
  • Cell Biology

Background:

  • Death receptors (DRs) and their ligands, part of the tumor necrosis factor (TNF) superfamily, are critical for epidermal development and maintenance.
  • Targeting DRs primarily induces apoptosis, a key cellular process.
  • Dysregulation of DR signaling is implicated in various skin pathologies.

Purpose of the Study:

  • To review the role of death receptor signaling in the pathogenesis of specific cutaneous diseases.
  • To highlight the connection between aberrant DR signaling and skin conditions.

Main Methods:

  • Literature review focusing on death receptor signaling pathways.
  • Analysis of evidence linking DR dysregulation to specific dermatological conditions.

Main Results:

  • Death receptor interactions are essential for epidermal homeostasis.
  • Apoptosis is the primary outcome of DR activation.
  • Evidence supports the involvement of DR signaling dysregulation in toxic epidermal necrolysis, graft versus host disease, and skin cancer.

Conclusions:

  • Death receptor signaling is a critical factor in skin biology.
  • Aberrant DR pathways contribute significantly to the development of severe skin diseases.
  • Understanding these interactions offers insights into potential therapeutic targets for cutaneous disorders.

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