Related Experiment Video

Updated: Jul 11, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Receptors in skin ageing and antiageing agents

Ilaria Ghersetich1, Michela Troiano, Vincenzo De Giorgi

  • 1Department of Dermatology, University of Florence, Via Lorenzo il Magnifico 104, 50129 Florence, Italy. i.ghersetich@dermatology.it

Dermatologic Clinics
|October 2, 2007
PubMed

Insights

Skin ageing involves irreversible changes, but dermatology seeks to reverse signs of ageing and photodamage. Advances in skin biology offer new treatments and therapeutic agents for skin ageing.

Area of Science:

  • Dermatology
  • Skin Biology
  • Molecular Biology

Background:

  • Skin ageing is a natural, irreversible process with significant ultrastructural and physiological changes.
  • Dermatology research focuses on mitigating ageing signs and photodamage for cosmetic and preventative purposes.
  • Photodamage and skin ageing are complex processes with increasing research into underlying mechanisms.

Purpose of the Study:

  • To review recent advances in understanding skin ageing mechanisms.
  • To explore new therapeutic strategies for preventing and reversing skin ageing and photodamage.
  • To highlight the potential of targeting key receptors for future treatments.

Main Methods:

  • Literature review of recent advances in skin biology and dermatology.
  • Analysis of current understanding of photoageing mechanisms.
  • Exploration of potential therapeutic targets and agents.

Main Results:

  • Recent advances have clarified the mechanisms of photoageing.
  • New treatments are emerging to prevent and reverse skin ageing.
  • Understanding key receptors is crucial for developing novel therapeutic agents.

Conclusions:

  • Continued research into skin ageing mechanisms is vital.
  • Targeting specific receptors holds promise for future dermatological therapies.
  • The development of new therapeutic agents for skin ageing is anticipated.

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...