Related Experiment Video

Updated: Jul 11, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

The cardiovascular risk factor, left ventricular hypertrophy, is highly prevalent in stable, treated angina pectoris

Donald Swee Cheng Ang1, Stuart D Pringle, Allan D Struthers

  • 1Division of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK. d.s.c.ang@dundee.ac.uk

American Journal of Hypertension
|October 2, 2007
PubMed

Insights

Left ventricular hypertrophy (LVH) affects 73% of patients with stable angina. Many with LVH have normal blood pressure, indicating LVH is a key factor in coronary artery disease (CAD) risk.

Area of Science:

  • Cardiology
  • Cardiovascular Disease
  • Hypertension Research

Background:

  • Left ventricular hypertrophy (LVH) is a reversible factor in cardiac death for coronary artery disease (CAD) patients.
  • The overall impact of LVH in CAD depends on its prevalence.
  • Assessing LVH prevalence in stable, treated angina patients and its relation to blood pressure (BP) is crucial.

Purpose of the Study:

  • To determine the prevalence of left ventricular hypertrophy (LVH) in patients with stable, treated angina.
  • To investigate the relationship between LVH and blood pressure (BP) in this patient group.

Main Methods:

  • Recruited 322 consecutive patients with confirmed coronary artery disease (CAD).
  • Performed echocardiographic LV mass measurements.
  • Correlated LV mass with both office and 24-h ambulatory blood pressure (BP).

Main Results:

  • Of 267 patients with LV mass data, 195 (73%) exhibited LVH.
  • The LVH group had a mean 24-h ambulatory BP of 125/68 mm Hg.
  • 62% of LVH patients had nonhypertensive 24-h BP readings.
  • Independent predictors of LVH included hypertension history, BMI, and age.

Conclusions:

  • Echocardiographic LVH is highly prevalent in stable, treated angina patients.
  • A majority of these patients with LVH had nonhypertensive BP readings during the study.
  • Further research is needed to evaluate if treating LVH reduces premature death risk in CAD.
Abstract

More Related Videos

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats07:41

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Published on: March 1, 2022

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Angina II: Classification01:27

Angina II: Classification

Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...