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Published on: November 15, 2024

Influence of hyperglycemia on stroke mortality

Y Wang1, L L Lim, C Levi

  • 1Centre for Clinical Epidemiology and Biostatistics, Royal Newcastle Hospital, Newcastle, New South Wales, Australia.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 2, 2007
PubMed

Insights

Hyperglycemia without diabetes independently increases in-hospital mortality risk in acute ischemic stroke patients. A trend of increasing mortality was observed across glucose and diabetes status groups.

Area of Science:

  • Neurology
  • Endocrinology
  • Public Health

Background:

  • The prognostic significance of hyperglycemia in acute ischemic stroke remains debated.
  • Diabetes mellitus is a known risk factor for stroke and may influence outcomes.

Purpose of the Study:

  • To evaluate the independent prognostic value of hyperglycemia and diabetes on short-term and long-term mortality in acute ischemic stroke patients.
  • To clarify the controversial influence of hyperglycemia on stroke mortality.

Main Methods:

  • Retrospective cohort study of 416 acute ischemic stroke patients.
  • Patients categorized into four groups based on glucose levels and diabetes history.
  • Logistic regression and Cox proportional hazards models used to analyze in-hospital and 1-year mortality.

Main Results:

  • A significant trend of increasing in-hospital mortality was observed across the four groups (P < .001).
  • Hyperglycemia in patients without a history of diabetes was an independent predictor of in-hospital mortality (OR 3.0, P = .035).
  • Hyperglycemia, with or without diabetes, did not significantly predict 1-year mortality.

Conclusions:

  • Hyperglycemia in the absence of diabetes is independently associated with increased in-hospital mortality in acute ischemic stroke.
  • A clear trend of rising in-hospital mortality was noted with increasing hyperglycemia and diabetes status.
Abstract

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