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Updated: Jul 11, 2026
09:35
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
Influence of hyperglycemia on stroke mortality.
1Centre for Clinical Epidemiology and Biostatistics, Royal Newcastle Hospital, Newcastle, New South Wales, Australia.
Summary
Hyperglycemia without diabetes independently increases in-hospital mortality risk in acute ischemic stroke patients. A trend of increasing mortality was observed across glucose and diabetes status groups.
Area of Science:
- Neurology
- Endocrinology
- Public Health
Background:
- The prognostic significance of hyperglycemia in acute ischemic stroke remains debated.
- Diabetes mellitus is a known risk factor for stroke and may influence outcomes.
Purpose of the Study:
- To evaluate the independent prognostic value of hyperglycemia and diabetes on short-term and long-term mortality in acute ischemic stroke patients.
- To clarify the controversial influence of hyperglycemia on stroke mortality.
Main Methods:
- Retrospective cohort study of 416 acute ischemic stroke patients.
- Patients categorized into four groups based on glucose levels and diabetes history.
- Logistic regression and Cox proportional hazards models used to analyze in-hospital and 1-year mortality.
Main Results:
- A significant trend of increasing in-hospital mortality was observed across the four groups (P < .001).
- Hyperglycemia in patients without a history of diabetes was an independent predictor of in-hospital mortality (OR 3.0, P = .035).
- Hyperglycemia, with or without diabetes, did not significantly predict 1-year mortality.
Conclusions:
- Hyperglycemia in the absence of diabetes is independently associated with increased in-hospital mortality in acute ischemic stroke.
- A clear trend of rising in-hospital mortality was noted with increasing hyperglycemia and diabetes status.
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