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The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
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Related Experiment Video

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Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
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Published on: February 23, 2016

Neuropsychologic function in chronic carotid obstructive disease.

T Fukuda1, T Maruno, H Ito

  • 1Department of Neurosurgery, Hachiouji Medical Center, Tokyo Medical University, Tokyo, Japan.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 2, 2007
PubMed
Summary

Neuropsychologic function is often impaired in patients with internal carotid (IC) artery stenosis or occlusion, linked to cerebral circulatory issues and ischemic brain lesions. Addressing these circulatory problems may improve cognitive outcomes.

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Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
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Published on: August 11, 2023

Area of Science:

  • Neurology
  • Neuropsychology
  • Vascular Neurology

Background:

  • Internal carotid (IC) artery stenosis or occlusion can lead to cerebral circulatory impairment.
  • Neuropsychologic deficits are common in patients with cerebrovascular disease.

Purpose of the Study:

  • To investigate factors influencing neuropsychologic function in patients with high-grade internal carotid artery stenosis or occlusion.
  • To analyze the relationship between cerebral circulation, ischemic lesions, and cognitive performance.

Main Methods:

  • 52 patients with >70% IC artery stenosis/occlusion underwent neuropsychologic assessment using the Wechsler Adult Intelligence Scale (WAIS).
  • Analysis correlated cognitive function (WAIS IQ) with disease duration, lesion characteristics (side, number, size of infarction), and cerebral circulation status.
  • Patients were categorized based on cerebral circulation: normal, misery perfusion, or matched low perfusion.

Main Results:

  • Performance IQ was lower in patients with cerebral infarction compared to those without.
  • Patients with normal cerebral circulation exhibited the highest mean full-scale IQ.
  • Impaired cerebral circulation (misery perfusion, matched low perfusion) was associated with lower full-scale IQ and wider IQ distribution, particularly in those with longer disease duration.

Conclusions:

  • Internal carotid artery stenosis/occlusion frequently results in impaired neuropsychologic function.
  • Cerebral circulatory impairment, alongside ischemic lesions, likely contributes significantly to cognitive deficits in these patients.
  • Assessment of cerebral circulation is crucial for understanding neuropsychologic outcomes in IC artery disease.