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Assessment of Diffusion and Perfusion

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Related Experiment Video

Updated: Jul 11, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
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Published on: September 16, 2017

Delayed signal detection by diffusion-weighted imaging in brainstem infarction.

M Begemann1, A Silvers, C Tang

  • 1Department of Neurology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 2, 2007
PubMed
Summary
This summary is machine-generated.

Diffusion-weighted MRI (DW MRI) may miss early signs of brainstem infarction. Repeat diffusion-weighted imaging (DWI) days later can reveal abnormalities, aiding diagnosis.

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Diffusion-weighted magnetic resonance imaging (DW MRI) is a standard for acute hemispheric infarction.
  • Its effectiveness in diagnosing acute brainstem infarction is less understood.

Purpose of the Study:

  • To investigate the diagnostic utility of DW MRI in acute brainstem infarction.
  • To determine the optimal timing for detecting brainstem infarcts using DW MRI.

Main Methods:

  • Case series of 3 patients with suspected brainstem infarction.
  • Initial DW MRI performed 5-15 hours post-symptom onset.
  • Follow-up DW MRI conducted 2-5 days later.

Main Results:

  • Initial DW MRI scans were negative for abnormalities in all 3 cases.
  • Repeat DW MRI scans, performed days later, showed abnormalities in the expected brainstem regions.
  • Abnormalities detected by DWI appeared to develop later in brainstem infarcts compared to hemispheric infarcts.

Conclusions:

  • DW MRI may have a delayed sensitivity for detecting acute brainstem infarction.
  • Initially negative DWI results in suspected brainstem infarction warrant follow-up imaging.
  • Repeat DWI studies can be crucial for diagnosing brainstem infarcts when initial scans are inconclusive.