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Updated: Jul 11, 2026
08:18
Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model
Published on: February 8, 2022
Platelet count and function in spontaneous intracerebral hemorrhage
Wendy C Ziai1, Michel T Torbey, Thomas S Kickler
1Division of Neurosciences Critical Care, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. weziai@jhmi.edu
Summary
Platelet dysfunction and low platelet counts are common in patients with spontaneous intracerebral hemorrhage (ICH). These factors may contribute to larger hemorrhage size and progression.
Area of Science:
- Neurology
- Hematology
- Critical Care Medicine
Background:
- Impaired platelet function is linked to increased risk of intracerebral hemorrhage (ICH).
- The specific roles of platelet count and dysfunction in spontaneous ICH (SICH) remain unclear.
Purpose of the Study:
- To investigate platelet count and function in patients with SICH.
- To determine if platelet abnormalities correlate with ICH progression and size.
Main Methods:
- Retrospective case series comparing SICH patients to controls with neuromuscular disorders.
- Platelet counts and function tests performed on a subset of patients.
- ICH volume assessed via CT scans using the ABC/2 method.
Main Results:
- SICH patients showed significantly lower nadir platelet counts compared to controls.
- A fall in platelet count correlated with hematoma size increase.
- Low platelet counts were associated with larger ICH volumes.
- Platelet dysfunction was more prevalent in patients with larger ICH.
Conclusions:
- Platelet dysfunction is a common finding in SICH patients.
- Low platelet count and dysfunction may contribute to ICH expansion.
- Further research with larger sample sizes is warranted.
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