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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
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A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
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Related Experiment Video

Updated: Jul 11, 2026

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
08:39

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Published on: November 20, 2015

Multiple cerebellar infarcts: clinical and pathophysiologic features.

Shin-Ichi Terao1, Naofumi Miura, Yutaka Osano

  • 1Division of General Medicine, Department of Internal Medicine, Aichi Medical University School of Medicine, Aichi, Japan.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 2, 2007
PubMed
Summary
This summary is machine-generated.

Multiple isolated cerebellar ischemic lesions often present with vertigo, nausea, and ataxia. Atherothrombotic and embolic mechanisms, particularly involving the posterior inferior cerebellar artery (PICA) and superior cerebellar artery (SCA), are common causes.

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Last Updated: Jul 11, 2026

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
08:39

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Published on: November 20, 2015

Cerebellar Regional Dissection for Molecular Analysis
08:51

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Published on: December 5, 2020

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08:14

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Area of Science:

  • Neurology
  • Vascular Neurology
  • Neuroimaging

Background:

  • Cerebellar ischemic lesions can lead to significant neurological deficits.
  • Understanding the clinical presentation and vascular territories involved is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the clinical features, vascular territories, and underlying mechanisms of multiple isolated cerebellar ischemic lesions.

Main Methods:

  • Retrospective analysis of 15 patients with multiple isolated cerebellar infarcts.
  • Clinical data, neuroimaging findings (lesion location, vascular territories), and etiological factors were reviewed.

Main Results:

  • Common symptoms included vertigo, nausea, vomiting, headache, dysarthria, and cerebellar ataxia.
  • Lesions frequently involved posterior inferior cerebellar artery (PICA) and superior cerebellar artery (SCA) territories.
  • Vertebral artery occlusive disease was present in 60% of patients; atherothrombotic and embolic mechanisms were the primary causes.

Conclusions:

  • Multiple isolated cerebellar infarcts present with characteristic neurological symptoms.
  • Embolic and atherothrombotic mechanisms, often involving PICA and SCA, are key etiological factors.
  • Despite potential vascular abnormalities, the functional prognosis is generally good.