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Do high-density lipoprotein cholesterol levels influence stroke severity?

Nerses Sanossian¹, Jeffrey L Saver, Doojin Kim

¹Stroke Center, University of California at Los Angeles Medical Center, Los Angeles, California, USA.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association

|October 2, 2007

Summary

Low high-density lipoprotein (HDL) cholesterol is linked to increased stroke risk. In patients 50 or younger, low HDL levels correlated with more severe strokes, suggesting a potential protective effect of higher HDL in this age group.

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Area of Science:

Neurology
Cardiovascular Science
Biochemistry

Background:

Low serum high-density lipoprotein (HDL) cholesterol is a known risk factor for stroke.
Stroke severity significantly impacts patient outcomes.
The relationship between HDL levels and stroke severity, particularly in younger individuals, requires further investigation.

Purpose of the Study:

To investigate the association between low serum HDL cholesterol levels and stroke severity.
To determine if age modifies the relationship between HDL cholesterol and stroke severity.

Main Methods:

A cohort of 241 consecutive ischemic stroke patients was analyzed.
Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS).
Fasting serum HDL levels were measured, and the impact of low HDL (<35 mg/dL) and age on NIHSS was evaluated, controlling for confounders.

Main Results:

No significant association was found between low HDL and stroke severity in the overall patient group (NIHSS 6 vs. 5, P = .385).
In young patients (≤50 years), low HDL levels were significantly associated with increased stroke severity (NIHSS 15 vs. 4, P = .005).
This association in younger patients remained significant after adjusting for potential confounding factors (NIHSS 13 vs. 2, P = .01).

Conclusions:

Low serum HDL cholesterol is not generally associated with stroke severity.
A potential association exists between higher serum HDL levels and reduced stroke severity in patients aged 50 years and younger.