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Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron

Seung Yong Yoon1, Hyo In Choi, Jung Eun Choi

  • 1Department of Anatomy and Cell Biology, University of Ulsan College of Medicine, 388-1 PoongNap-Dong, SongPa-Gu, Seoul 138-736, Republic of Korea.

Biochemical and Biophysical Research Communications
|October 2, 2007
PubMed
Summary

Folate deficiency exacerbates Alzheimer's disease (AD) pathology, increasing tau phosphorylation and amyloid precursor protein (APP) levels. This may occur by inactivating protein phosphatase-2A (PP2A), a key enzyme in neurodegeneration.

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