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Autologous mesenchymal bone marrow stem cells: practical considerations.

Neil Scolding1, David Marks, Claire Rice

  • 1University of Bristol Institute of Clinical Neurosciences, Department of Neurology, Frenchay Hospital, Bristol BS16 1LE, UK. Diane.Millard@north-bristol.swest.nhs.uk

Journal of the Neurological Sciences
|October 2, 2007
PubMed
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Stem cell therapy for multiple sclerosis (MS) faces practical challenges. Research indicates clinical science is ready for patient testing, prompting a pilot study of autologous bone marrow cells in MS patients.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Clinical Trials

Background:

  • Multiple Sclerosis (MS) presents complex challenges for cell therapy application.
  • Key issues include cell type selection, axon loss, disease activity, delivery methods, outcome measurement, treatment timing, and patient safety.

Purpose of the Study:

  • To review progress in addressing practical challenges for cell therapy in MS.
  • To determine if clinical science has reached a stage for safe patient testing.
  • To justify the commencement of a pilot study for autologous bone marrow cell treatment in MS.

Main Methods:

  • Review of practical problems in cell therapy for MS.
  • Assessment of clinical science readiness for translation.
  • Initiation of a pilot/feasibility study.

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Main Results:

  • Significant progress has been made in addressing practical challenges for cell therapy in MS.
  • The 'translation threshold' for safe and appropriate clinical testing is deemed achievable.
  • A pilot study using autologous bone marrow cells has commenced in Bristol.

Conclusions:

  • Clinical science has advanced sufficiently to initiate stem cell treatments in MS patients.
  • A pilot study is underway to evaluate autologous bone marrow cell therapy for MS.
  • Addressing practical hurdles is crucial for the successful translation of cell therapies for neurological disorders.