Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interference and Decay01:16

Interference and Decay

Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the cerebellum's...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Implicit Memories01:24

Implicit Memories

Implicit memories, also known as non-declarative memories, are long-term memories that function outside of conscious awareness. These memories influence behavior and skills without explicit knowledge. This type of memory is evident in tasks like playing tennis, snowboarding, and texting. Implicit memory has three subsystems: procedural memory, conditioning, and priming. This type of memory is essential in various activities, from everyday tasks to specialized skills.
One key aspect of implicit...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mind-wandering content in major depressive disorder: A preregistered secondary analysis.

Journal of affective disorders·2026
Same author

Physiological Evidence for the Time-dependent Resolution of Response Conflicts.

Journal of cognitive neuroscience·2026
Same author

Precision fMRI reveals densely interdigitated network patches with conserved motifs in the lateral prefrontal cortex.

Neuron·2026
Same author

Neighborhood air pollution is associated with attenuated neurocognitive maturation over early adolescence.

Developmental cognitive neuroscience·2026
Same author

The exposome and attention-related brain networks jointly predict attention problems in early adolescence.

medRxiv : the preprint server for health sciences·2026
Same author

Joint Cognitive Models Reveal Sources of Robust Individual Differences in Conflict Processing.

Computational brain & behavior·2026

Related Experiment Video

Updated: Jul 11, 2026

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions
10:38

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

Published on: July 16, 2015

Neural mechanisms of proactive interference-resolution.

Derek Evan Nee1, John Jonides, Marc G Berman

  • 1Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109-1043, USA. dnee@umich.edu

Neuroimage
|October 2, 2007
PubMed
Summary

Cognitive control involves resolving proactive interference, where the brain filters out irrelevant information. This study shows both left ventrolateral prefrontal cortex (VLPFC) and left anterior prefrontal cortex (APFC) are crucial for this process across tasks.

More Related Videos

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
12:12

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

Related Experiment Videos

Last Updated: Jul 11, 2026

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions
10:38

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

Published on: July 16, 2015

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
12:12

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

Area of Science:

  • Cognitive Neuroscience
  • Neuroimaging
  • Human Brain Function

Background:

  • Mitigating interference from outdated information is vital for cognitive function.
  • Left ventrolateral prefrontal cortex (VLPFC) is implicated in interference resolution, but generalizability across tasks is unclear.
  • The role of left anterior prefrontal cortex (APFC) in proactive interference resolution requires further investigation.

Purpose of the Study:

  • To investigate the role of left VLPFC and left APFC in resolving proactive interference.
  • To determine if these regions' roles generalize across different cognitive tasks.
  • To elucidate the functional networks associated with proactive interference resolution.

Main Methods:

  • Event-related functional magnetic resonance imaging (fMRI) was employed.
  • Two distinct tasks were administered to the same subjects to assess cross-task generalizability.
  • Analysis focused on neural activity within left VLPFC, left APFC, and posterior cingulate gyrus.

Main Results:

  • Both left VLPFC and left APFC are significantly involved in proactive interference resolution across tasks.
  • Distinct functional networks associated with left VLPFC and left APFC suggest specialized roles.
  • The posterior cingulate gyrus showed unique involvement in memory facilitation when short- and long-term memory converged.

Conclusions:

  • Left VLPFC and left APFC are key brain regions for resolving proactive interference.
  • Dissociable functional roles exist between left VLPFC and left APFC in this process.
  • Findings refine models of proactive interference resolution and memory integration.