SSX2IP: an emerging role in cancer
Angela Breslin1, Frances A K Denniss, Barbara-ann Guinn
1Department of Haematological Medicine, King's College London School of Medicine, The Rayne Institute, 123 Coldharbour Lane, London SE5 9NU, UK.
Biochemical and Biophysical Research Communications
|October 2, 2007
Summary
Synovial Sarcoma X breakpoint 2 Interacting Protein (SSX2IP) is emerging as a key player in cancer. Its unique expression patterns and cell surface localization during mitosis suggest SSX2IP may be a promising target for leukemia immunotherapy.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- The function of Synovial Sarcoma X breakpoint 2 Interacting Protein (SSX2IP) in human cells is largely unknown.
- SSX2IP has known roles in cell adhesion in rodents and circadian rhythms in chickens.
- In humans, SSX2IP was identified via interaction with the cancer-testis gene SSX2, but unlike SSX2, it is expressed in various normal and fetal tissues.
Purpose of the Study:
- To explore the emerging role of SSX2IP in cancer.
- To discuss the known and potential functions of SSX2IP across different species.
- To evaluate SSX2IP as a potential target for leukemia immunotherapy.
Main Methods:
- Review of existing literature on SSX2IP function and expression.
- Analysis of SSX2IP localization in transfected human cells (nucleus and cytoplasm).
- Observation of SSX2IP expression on myeloid leukemia cells during mitosis.
Main Results:
- SSX2IP exhibits varied expression patterns, including localization to the cell surface of myeloid leukemia cells during mitosis.
- Evidence suggests SSX2IP's involvement in cellular processes relevant to cancer.
- SSX2IP's distinct expression profile differentiates it from SSX2.
Conclusions:
- SSX2IP has a complex and emerging role in human cells and cancer.
- The cell surface expression of SSX2IP during mitosis in leukemia cells presents a potential therapeutic window.
- SSX2IP is a promising candidate for developing novel leukemia immunotherapies.
Related Concept Videos
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...