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Updated: Jul 11, 2026

Method of Studying Palatal Fusion using Static Organ Culture

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

Prophylactic antibiotics and surgery for primary clefts.

A G Smyth¹, G J Knepil

¹Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds, West Yorkshire LS2 9NS, United Kingdom. alistair.smyth@leedsth.nhs.uk

The British Journal of Oral & Maxillofacial Surgery

|October 2, 2007

Summary

Current guidelines lack evidence for antibiotic prophylaxis in cleft lip and palate repair. A UK survey revealed inconsistent practices among surgeons, highlighting the need for clinical trials to establish national recommendations for prophylactic antibiotics.

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Last Updated: Jul 11, 2026

Method of Studying Palatal Fusion using Static Organ Culture

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

Area of Science:

Plastic Surgery
Oral and Maxillofacial Surgery
Pediatric Surgery

Background:

No current evidence-based guidelines exist for antibiotic prophylaxis in cleft lip and palate repair.
Practices regarding prophylactic antibiotic use in cleft surgery vary significantly.
Regional cleft centers in the UK were established, prompting a review of current practices.

Purpose of the Study:

To investigate the current use of antibiotic prophylaxis in primary cleft lip and palate repair in the UK.
To identify the level of consensus and disparities in antibiotic prophylaxis practices among cleft surgeons.
To highlight the need for evidence-based recommendations in this surgical area.

Main Methods:

A postal questionnaire was distributed to cleft surgeons across the UK in 2004.
The questionnaire aimed to gather information on the routine use of antibiotic prophylaxis for primary cleft lip and palate repair.
Data analysis focused on identifying patterns and variations in reported practices.

Main Results:

A significant lack of consensus was observed regarding the use of antibiotic prophylaxis.
Wide disparities in prescribing practices were evident among different cleft centers.
The study identified a clear need for standardized, evidence-based protocols.

Conclusions:

There is a lack of consensus on antibiotic prophylaxis for primary cleft lip and palate repair.
The findings underscore the necessity for a randomized controlled clinical trial.
Establishing national recommendations for rational prophylactic antibiotic use in cleft surgery is crucial.