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Updated: Jul 11, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Signalling pathways mediating type I interferon gene expression
Michael R Edwards1, Louise Slater, Sebastian L Johnston
1Department of Respiratory Medicine, National Heart and Lung Institute, MRC Centre in Allergic Mechanisms of Asthma, St Marys Campus, Norfolk Place, London W2 1PG, UK. michael.edwards@imperial.ac.uk
Abstract:
Type I interferon-alpha/beta play an essential role in immunity to viruses. While interferon-beta has been used as a model of a complex promoter, many of the signalling pathways leading to interferon-beta gene expression remain controversial. Recent milestones include the discovery of Toll-like receptors and RNA helicases that signal via a novel kinase complex composed of I kappa B kinase-iota/epsilon or TANK binding kinase-1. This review provides a timely summary of this rapidly expanding field, focusing specifically on the various viral RNA binding molecules and their associated signalling pathways.
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