Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structured pharmaceutical interviews enhance knowledge and medication adherence in DOAC therapy: Insights from the EDUC-AOD study.

Patient education and counseling·2025
Same author

Alterations in DNA Damage Repair Genes Before and After Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer.

European urology open science·2024
Same author

Long-Term Recurrence Risk, Metastatic Potential, and Length of Cystoscopic Surveillance of Low-Grade Nonmuscle-Invasive Bladder Cancer.

The Journal of urology·2024
Same author

Low SMARCD3 expression is associated with poor prognosis in patients with prostate cancer.

The Prostate·2024
Same author

Accelerating histopathology workflows with generative AI-based virtually multiplexed tumour profiling.

Nature machine intelligence·2024
Same author

Histological sampling protocols for transurethral resection of prostate specimens need reappraisal.

Histopathology·2024

Related Experiment Video

Updated: Jul 11, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

p63 gene expression study and early bladder carcinogenesis.

Eva Compérat1, Ivan Bièche, Delphine Dargère

  • 1CNRS UMR 8149, Faculté de Pharmacie Paris V, Paris, France. evacomperat@yahoo.fr

Urology
|October 2, 2007
PubMed
Summary
This summary is machine-generated.

p63 gene expression decreases in early bladder cancer, indicating its role in urothelial carcinoma development. This deregulation is detectable even in the initial stages of the disease.

More Related Videos

Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Related Experiment Videos

Last Updated: Jul 11, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Area of Science:

  • Molecular Oncology
  • Urothelial Carcinogenesis

Background:

  • Urothelial carcinoma is an aggressive and common cancer.
  • Understanding early molecular mechanisms is crucial for bladder cancer development.

Purpose of the Study:

  • To analyze gene expression levels of uroplakin II, TBP/RNA control gene (NM_00394), and p63 isoforms (TAp63, deltaNp63).
  • To investigate early molecular changes in bladder carcinogenesis.

Main Methods:

  • Real-time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) on normal bladder, noninvasive, and muscle-invasive bladder carcinoma tissues (n=49).
  • Immunohistochemistry on tissue microarrays to confirm protein level changes.

Main Results:

  • p63 gene expression was significantly deregulated, showing decreased levels in early cancer compared to normal bladder tissue.
  • Immunohistochemistry confirmed the down-regulation of p63 protein in early-stage bladder cancer.

Conclusions:

  • p63 is abnormally expressed in the early stages of urothelial carcinoma.
  • p63 deregulation is a significant molecular event in early bladder carcinogenesis.