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Updated: Jul 11, 2026

Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
Current controversies regarding pain assessment in neonates
Manon Ranger1, C Céleste Johnston, K J S Anand
1McGill University, School of Nursing, Montreal, Canada. manon.ranger@mail.mcgill.ca
Insights
Despite numerous infant pain assessment tools, under-treated pain persists in Neonatal Intensive Care Units. Newer technologies may help identify sensitive pain indicators for preterm and term infants.
Area of Science:
- Neonatal care
- Pain management
- Infant development
Background:
- Over 40 pain assessment methods exist for infants, yet under-treated pain is common in Neonatal Intensive Care Units (NICUs).
- Infant pain responses vary with gestational age, and discrepancies exist between behavioral and physiological pain indicators.
- Accurate pain assessment in neonates is crucial for effective clinical management.
Purpose of the Study:
- To review current controversies in pain assessment for preterm and term infants.
- To identify key issues and define future research directions.
- To explore the potential of new technologies in verifying infant pain perception.
Main Methods:
- Review of existing literature on infant pain assessment methods.
- Analysis of factors influencing pain response variability in neonates.
- Discussion of discrepancies between behavioral and physiological pain indicators.
- Exploration of emerging technologies for pain assessment.
Main Results:
- Unrecognized and under-treated pain remains a significant problem in NICUs.
- Factors such as gestational age influence the infant's pain response.
- Discrepancies between behavioral and physiological pain indicators are frequently reported.
- New technologies offer potential for verifying infant pain perception and identifying sensitive indicators.
Conclusions:
- Pain assessment in preterm and term infants presents ongoing challenges.
- Further research is needed to refine pain assessment tools and strategies.
- Technological advancements may improve the accuracy and specificity of infant pain assessment.
- A dialogue is necessary to advance the field of neonatal pain management.
Abstract:
Although over 40 methods of pain assessment in infants are available for use in clinical practice, unrecognized and under-treated pain remains one of the most commonly reported problems within the Neonatal Intensive Care Units. A number of factors have been found to account for differences in the robustness of the pain response in neonates of varying gestational ages. Discrepancies between behavioral and physiological pain indicators have also been reported. With newer technologies, there is an opportunity not only to verify infant pain perception, but these tools may allow an identification of which of the observed indicators are most sensitive in particular clinical situations. The current controversies regarding pain assessment in preterm and term infants are reviewed to define the most important issues and to develop a dialogue for future directions.
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