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Metabolic effects of nitrendipine
G Paolisso1, E Aceto, G Cennamo
1Institute of Gerontology and Geriatrics, 1st Faculty of Medicine, University of Naples, Italy.
Clinical Therapeutics
|November 1, 1991
Summary
Nitrendipine effectively lowered blood pressure in elderly patients with isolated systolic hypertension. This study found nitrendipine safe and beneficial for managing hypertension in older adults.
Area of Science:
- Cardiology
- Geriatrics
- Pharmacology
Background:
- Isolated systolic hypertension is a common condition in the elderly.
- Effective and safe treatments for elderly patients with isolated systolic hypertension are needed.
Purpose of the Study:
- To evaluate the safety and clinical efficacy of nitrendipine for treating isolated systolic hypertension in elderly patients.
Main Methods:
- A randomized, double-blind, placebo-controlled study.
- 20 elderly patients with isolated systolic hypertension were enrolled.
- Patients received either 20 mg of nitrendipine or a placebo daily for 60 days.
Main Results:
- Nitrendipine significantly reduced both systolic and diastolic blood pressure.
- Mean systolic blood pressure decreased from 180 to 155 mmHg.
- Mean diastolic blood pressure decreased from 92 to 80 mmHg.
- Heart rate, laboratory test results, and oral glucose tolerance tests showed no significant changes.
Conclusions:
- Nitrendipine is a safe and effective treatment for isolated systolic hypertension in elderly patients.
- Nitrendipine demonstrates significant blood pressure-lowering effects without adverse effects on heart rate or glucose metabolism.