Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Harvesting, revascularization and innervation of a laryngeal transplant.

European annals of otorhinolaryngology, head and neck diseases·2025

Same author

Contribution of ultrasound in the management of ballistic nerve injury during the 2020 Nagorno-Karabakh war.

Journal of ultrasound·2024

Same author

Reversible posterior leukoencephalopathy syndrome (RPLS) in a patient with chronic lymphocytic leukemia (CLL) treated with Acalabrutinib, a Bruton's tyrosine kinase (BTK) inhibitor: a case report.

Acta neurologica Belgica·2024

Same author

The pink side of spondyloarthritis: a narrative review across pathogenesis and clinical manifestations in women.

Reumatismo·2024

Same author

Laryngeal graft after total laryngectomy in humans: A SWiM analysis.

European annals of otorhinolaryngology, head and neck diseases·2023

Same author

2023: First laryngeal transplantation in France by the "ECLAT" group!

European annals of otorhinolaryngology, head and neck diseases·2023

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach

Published on: May 23, 2025

[Hand allografts: experience from Lyon team].

A Gazarian¹, D-O Abrahamyan, P Petruzzo

¹Chirurgie de la main et du membre supérieur, clinique du Parc, 155, boulevard Stalingrad, 69006 Lyon, France. a.gazarian@cliniqueduparclyon.com

Annales De Chirurgie Plastique Et Esthetique

|October 2, 2007

Summary

Hand allografting, a clinical trial for traumatic amputees, shows promising sensorimotor recovery and social adaptation. Despite manageable complications, this composite tissue allotransplantation offers better outcomes than prostheses.

More Related Videos

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Published on: June 13, 2025

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Published on: April 26, 2019

Related Experiment Videos

Last Updated: Jul 11, 2026

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach

Published on: May 23, 2025

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Published on: June 13, 2025

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Published on: April 26, 2019

Area of Science:

Transplantation immunology
Reconstructive surgery
Clinical experimentation

Context:

Hand allografting is an experimental treatment for bilateral traumatic amputees in France.
Pioneering experience from the Lyon team is detailed, involving seven hand transplantations between 1998 and 2007.
The study focuses on patients with amputations at the wrist or mid-forearm, with a significant delay since hand loss.

Purpose:

To report the Lyon team's experience with hand allografting in traumatic amputees.
To evaluate the clinical, analytical, and functional outcomes of hand transplantation.
To assess the safety and efficacy of immunosuppressive protocols in composite tissue allotransplantation.

Summary:

Four patients underwent seven hand transplantations, with bilateral cases showing favorable evolution and good to excellent sensorimotor recovery.
Acute rejections were managed effectively with oral prednisone and topical immunosuppressants; no severe long-term complications were noted.
Functional recovery in bilateral recipients surpassed outcomes from myoelectric prostheses, indicating the potential of hand allografting.

Impact:

Hand allografting demonstrates potential as a viable treatment option for traumatic hand loss, offering superior functional restoration compared to current prosthetics.
The study supports the advancement of composite tissue allotransplantation (CTA) research and clinical application.
Encouraging results warrant further long-term research and global monitoring to establish authorization criteria and understand CTA mechanisms.