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Related Experiment Video

Updated: Jul 11, 2026

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Published on: October 9, 2018

Intraperitoneal transfusion in severe, early-onset Rh isoimmunization.

David T Howe¹, George D Michailidis

¹Wessex Fetal and Maternal Medicine Unit, Princess Anne Hospital, Southampton, United Kingdom.

Obstetrics and Gynecology

|October 2, 2007

Summary

Intraperitoneal transfusions effectively managed severe Rhesus disease in early pregnancy. This method prevented fetal anemia and loss, offering a viable treatment for Rh isoimmunization.

Related Experiment Videos

Last Updated: Jul 11, 2026

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Published on: October 9, 2018

Area of Science:

Maternal-Fetal Medicine
Immunology
Hematology

Background:

Rh isoimmunization poses a significant risk to pregnancies, particularly in cases of severe, early-onset disease.
Previous pregnancies complicated by Rh isoimmunization require careful management to prevent fetal complications.

Observation:

A series of five women with severe, early-onset Rh isoimmunization were treated with intraperitoneal transfusions starting at 15-16 weeks gestation.
Transfusions were administered weekly until intravascular access was established for continued treatment.
Maternal anti-D immune globulin levels ranged from 24-244 IU initially.

Findings:

No fetus exhibited severe anemia at the time of the first intravascular transfusion, with the lowest hemoglobin recorded at 8.9 g/dL.
The treatment regimen resulted in no fetal losses.
Middle cerebral artery peak systolic velocity demonstrated a positive response to intraperitoneal transfusions, correlating with fetal hemoglobin levels even in early gestation.

Implications:

Intraperitoneal transfusion is a successful management strategy for severe, early-onset Rhesus disease.
This approach can prevent fetal anemia and loss, improving pregnancy outcomes.
Monitoring middle cerebral artery peak systolic velocity is a valuable tool for assessing fetal status in Rh isoimmunization during early pregnancy.