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Bone-alkaline phosphatase as indicator of bone formation
J P van Straalen1, E Sanders, M F Prummel
1Department of Clinical Chemistry, Academic Medical Centre, Amsterdam, The Netherlands.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|September 14, 1991
Summary
Bone-alkaline phosphatase levels indicate bone formation changes. Monitoring this enzyme helps assess osteoporosis risk from corticosteroids and bone synthesis from cyclosporin.
Area of Science:
- Biochemistry
- Endocrinology
- Pharmacology
Background:
- Oral corticosteroids can increase osteoporosis risk.
- Cyclosporin treatment may enhance bone synthesis.
- Bone-alkaline phosphatase (BALP) is a marker of bone formation.
Purpose of the Study:
- To evaluate BALP as a monitoring parameter for bone metabolism changes.
- To assess BALP levels in patients on oral corticosteroids.
- To assess BALP levels in patients on cyclosporin.
Main Methods:
- Measurement of bone-alkaline phosphatase levels.
- Patient groups included those at risk of osteoporosis (corticosteroid users) and increased bone synthesis (cyclosporin users).
Main Results:
- A significant decrease in BALP was observed during corticosteroid treatment.
- A significant increase in BALP was observed during cyclosporin treatment.
Conclusions:
- Bone-alkaline phosphatase is a valuable indicator for monitoring bone formation.
- BALP can help track bone metabolism shifts in patients undergoing specific medical treatments.