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Osteoclasts in Bone Remodeling

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Related Experiment Video

Updated: Jul 11, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

[Mechanisms of bone calcification].

¹The University of Tokyo, Graduate School of Medicine, Department of Cartilage & Bone Regeneration (Fujisoft).

Clinical Calcium

|October 2, 2007

Summary

Bone calcification involves hydroxyapatite crystallization on collagen matrices, regulated by osteoblasts. This process occurs in extracellular spaces, with osteoblasts controlling mineral and organic interactions.

Area of Science:

Bone biology
Biomineralization
Extracellular matrix

Context:

Bone calcification is a critical biomineralization process.
Hydroxyapatite crystallization occurs on type I collagen matrices.
This process takes place in extracellular spaces.

Purpose:

To overview the mineral and organic environments in bone calcification areas.
To describe the roles of osteoblasts in regulating mineral/organic interactions during calcification.

Summary:

Osteoblasts play a crucial role in bone calcification by controlling hydroxyapatite crystallization.
They regulate this process through the secretion of matrix proteins and enzymes.
The interplay between mineral and organic components is essential for bone formation.

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A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes

Published on: February 24, 2023

Related Experiment Videos

Last Updated: Jul 11, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

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Published on: June 24, 2018

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes

Published on: February 24, 2023

Impact:

Understanding osteoblast function in biomineralization is key to bone health.
This knowledge can inform therapeutic strategies for bone diseases.
Elucidates the mechanisms of skeletal development and maintenance.