Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...

Opioid Receptors: Overview

Opioid Receptors: Overview

Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2, D-Pen5]-enkephalin or DPDPE for...

G Protein-coupled Receptors

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...

G Protein-coupled Receptors

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...

Transducer Mechanism: G Protein–Coupled Receptors

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Redox-driven mineral and organic associations in Jezero Crater, Mars.

Nature·2025

Same author

Examining the impact of attentional focus and partner gaze on interpersonal coordination.

Psychonomic bulletin & review·2025

Same author

Partner gaze shapes the relationship between symptoms of psychopathology and interpersonal coordination.

Scientific reports·2024

Same author

Aqueously altered igneous rocks sampled on the floor of Jezero crater, Mars.

Science (New York, N.Y.)·2022

Same author

An olivine cumulate outcrop on the floor of Jezero crater, Mars.

Science (New York, N.Y.)·2022

Same author

Homogeneity assessment of the SuperCam calibration targets onboard rover perseverance.

Analytica chimica acta·2022

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

BRET-based G Protein Biosensors for Measuring G Protein-Coupled Receptor Activity in Live Cells

BRET-based G Protein Biosensors for Measuring G Protein-Coupled Receptor Activity in Live Cells

Published on: November 7, 2025

Novel cannabinoid receptors.

¹Department of Screening and Compound Profiling, Molecular Discovery Research, GlaxoSmithKline, Essex, UK. andrew.j.brown@gsk.com

British Journal of Pharmacology

|October 2, 2007

Summary

Cannabinoids exert physiological effects through known receptors, but some actions remain unexplained. This review explores novel cannabinoid targets, GPR55 and GPR119, which may clarify these non-CB1/CB2 receptor pathways.

Area of Science:

Pharmacology
Neuroscience
Molecular Biology

Background:

Cannabinoids mediate physiological effects via CB1, CB2 receptors, and TRPV1 channels.
Several cannabinoid-evoked actions are not explained by these classical targets, suggesting additional receptors.

Purpose of the Study:

To introduce non-CB1/CB2 receptor pharmacology.
To summarize current knowledge on GPR55 and GPR119 as potential novel cannabinoid receptors.
To explore the phylogenetic origin and explanatory role of these new receptors.

Main Methods:

Review of existing literature on cannabinoid pharmacology.
Analysis of studies involving genetically modified mice lacking known cannabinoid receptors.
Examination of research implicating orphan G protein-coupled receptors (GPCRs) like GPR55 and GPR119.

More Related Videos

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

Related Experiment Videos

Last Updated: Jul 11, 2026

BRET-based G Protein Biosensors for Measuring G Protein-Coupled Receptor Activity in Live Cells

BRET-based G Protein Biosensors for Measuring G Protein-Coupled Receptor Activity in Live Cells

Published on: November 7, 2025

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

Main Results:

Evidence suggests the existence of non-CB1/CB2 receptors mediating cannabinoid pharmacology.
GPR55 and GPR119 are proposed as novel cannabinoid receptors, with GPR55 activated by various ligands and GPR119 by oleoylethanolamide.

Conclusions:

GPR55 and GPR119 represent promising candidates for previously unidentified cannabinoid receptors.
Further research is needed to elucidate the precise roles and mechanisms of these non-classical receptors in cannabinoid signaling.