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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Updated: Jul 11, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Published on: February 15, 2022

[Ocular changes induced by chemotherapy].

Alessandra Pinheiro Chaves1, José Alvaro Pereira Gomes, Ana Luisa Höfling-Lima

  • 1Departamento de Oftalmologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil. sanchaves@gmail.com

Arquivos Brasileiros De Oftalmologia
|October 2, 2007
PubMed
Summary

Chemotherapy can cause ocular side effects, including changes in tear film and the ocular surface, impacting patient comfort and vision. This study found significant tear film alterations and punctate epitheliopathy in patients undergoing chemotherapy.

Related Experiment Videos

Last Updated: Jul 11, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Area of Science:

  • Ophthalmology
  • Oncology
  • Pharmacology

Context:

  • Antineoplastic agents improve cancer survival but can cause significant side effects.
  • Ocular toxicity is a known complication of chemotherapy, affecting the ocular surface and tear film.
  • Mucositis is a common chemotherapy-induced side effect.

Purpose:

  • To investigate chemotherapy-induced ocular surface changes.
  • To correlate these changes with chemotherapy treatment and mucositis.
  • To assess the impact of chemotherapy on tear film stability and ocular surface health.

Summary:

  • Chemotherapy significantly decreased tear breakup time (p<0.0001) and increased punctate epitheliopathy (78.4%) in patients.
  • While Schirmer test results showed no significant pre- vs. post-chemotherapy changes, biomicroscopy confirmed tear film alterations.
  • Chemotherapy-induced mucositis affects conjunctival mucosa, evidenced by subjective symptoms and objective findings like impression cytology.

Impact:

  • Highlights the prevalence and clinical significance of ocular surface toxicity during chemotherapy.
  • Underscores the need for ophthalmological monitoring in patients receiving antineoplastic agents.
  • Provides evidence for chemotherapy's direct impact on tear film dynamics and ocular surface integrity.