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Updated: Jul 11, 2026
12:40
Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
Published on: April 6, 2015
Interrelationship among asthma, atopy, and helminth infections
Eduardo Vieira Ponte1, José Angelo Rizzo, Alvaro Augusto Cruz
1Programa de Pós-Graduação em Medicina e Saúde, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brasil. evponte@yahoo.com.br
Summary
Helminth infections may reduce allergic disease symptoms and skin test reactivity. Evidence suggests helminths modulate immune responses, offering potential new treatments for immune system disorders.
Area of Science:
- Immunology
- Infectious Diseases
- Allergy Research
Background:
- The relationship between helminth infections, atopy, and asthma is complex and debated.
- Some studies suggest helminths may suppress allergic responses, while others show controversy.
Purpose of the Study:
- To review the literature on the interrelationship among helminth infections, atopy, and asthma.
- To explore the potential of helminth infections in modulating immune responses for therapeutic purposes.
Main Methods:
- A nonsystematic literature review was conducted.
- Publications on helminth infections, atopy, and asthma were analyzed.
Main Results:
- Controversy exists regarding geohelminth infections' effect on allergy.
- Studies on Schistosoma spp. suggest inhibition of skin allergy tests and asthma symptoms.
- In vitro studies indicate helminthiases inhibit T helper 1 and T helper 2 immune responses.
Conclusions:
- Helminth infections may play a role in modulating immune responses relevant to allergic diseases.
- This modulation presents potential therapeutic avenues for immune system disorders.
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