Related Experiment Video
Updated: Jul 11, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
Neurochemical changes in the aging process: implications in medication in the elderly
1St. Peter's Middle College House, 190 College Road, Birmingham, UK. ebereanyanwu@msn.com
Aging involves inevitable neurochemical changes that influence elderly medication. While aging cannot be prevented, understanding these changes is crucial for effective treatment strategies in older adults.
Area of Science:
- Gerontology and Neuroscience
- Pharmacology and Therapeutics
Background:
- Aging is a natural developmental process influenced by lifestyle and disease.
- Neurochemical alterations characterize aging, impacting physiological and behavioral functions.
- Medication efficacy and safety in the elderly are significantly affected by these changes.
Purpose of the Study:
- To evaluate neurochemical changes associated with the aging process.
- To explore the relevance of these neurochemical changes in elderly medication.
- To provide a comprehensive review of age-related neuroanatomical, physiological, and neurobehavioral shifts pertinent to pharmacotherapy.
Main Methods:
- Review of existing literature on neurochemical changes during aging.
- Analysis of neuroanatomical, physiological, and neurobehavioral alterations.
- Correlation of age-related changes with medication effects in the elderly.
Main Results:
- Identified key neurochemical shifts occurring with advanced age.
- Demonstrated the impact of these neurochemical changes on drug interactions and metabolism.
- Highlighted the importance of considering neurobiological factors in geriatric pharmacotherapy.
Conclusions:
- Neurochemical changes in aging are critical determinants of medication response in the elderly.
- A thorough understanding of age-related neurobiology is essential for optimizing medication regimens.
- Further research into targeted geriatric pharmacotherapy is warranted based on neurochemical profiles.
More Related Videos
10:13Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
10:19Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
Published on: August 22, 2014
Related Concept Videos
Drug Dosing: Geriatric Patients
Pharmacodynamics in Geriatric Patients: Effects of Age
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion