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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
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Types of Toxins01:36

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
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Environmental pollutants like...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Related Experiment Video

Updated: Jul 11, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Systemic autoimmune disease mortality and occupational exposures.

L S Gold1, M H Ward, M Dosemeci

  • 1Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. lgold@fhcrc.org

Arthritis and Rheumatism
|October 2, 2007
PubMed
Summary

Occupational exposures in farming and industry may increase the risk of death from systemic autoimmune diseases. This study identifies potential links for future research into disease causes.

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Area of Science:

  • Epidemiology
  • Occupational Health
  • Immunology

Background:

  • Systemic autoimmune diseases pose a significant health burden.
  • Understanding occupational risk factors is crucial for prevention.

Purpose of the Study:

  • To generate hypotheses on occupational exposures linked to systemic autoimmune diseases.
  • To investigate associations between specific occupations and mortality from autoimmune conditions.

Main Methods:

  • Analysis of US death certificates from 26 states for rheumatoid arthritis, lupus, systemic sclerosis, and other systemic autoimmune diseases.
  • Calculation of odds ratios to assess the association between occupation and autoimmune disease death.
  • Utilized job-exposure matrices to estimate risks from specific occupational exposures.

Main Results:

  • Farming occupations showed an association with death from systemic autoimmune diseases (OR 1.3).
  • Industrial jobs, including mining and textile machine operation, were linked to increased mortality.
  • Occupational exposures to animals and pesticides were also associated with higher risks.

Conclusions:

  • Occupational exposures in farming and industrial sectors are potential contributors to systemic autoimmune diseases.
  • The findings provide a basis for further research into the etiology of these conditions.