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Laser Doppler flowmetry for assessing localized scleroderma in children.

Lisa Weibel1, Kevin J Howell, Maria Teresa Visentin

  • 1Great Ormond Street Hospital for Children, London, UK. lisaweibel@yahoo.de

Arthritis and Rheumatism
|October 2, 2007
PubMed
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Laser Doppler flowmetry (LDF) effectively detects disease activity in pediatric localized scleroderma, outperforming infrared thermography. This noninvasive technique aids in managing children with this condition.

Area of Science:

  • Pediatric Dermatology
  • Rheumatology
  • Medical Diagnostics

Background:

  • Assessing disease activity in pediatric localized scleroderma is challenging.
  • Noninvasive diagnostic tools are needed for accurate management.

Purpose of the Study:

  • To compare laser Doppler flowmetry (LDF) and infrared thermography for detecting localized scleroderma activity in children.
  • To evaluate the diagnostic accuracy of LDF versus thermography.

Main Methods:

  • 41 children with localized scleroderma had 111 lesions assessed clinically, via LDF, and thermography.
  • Blood flow and temperature differences were measured against unaffected skin.
  • Sensitivity and specificity of LDF and thermography were compared.

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Main Results:

  • LDF showed a significant increase in blood flow for active lesions (+89%) vs. inactive lesions (+11%).
  • Thermography showed a smaller temperature difference between active and inactive lesions.
  • LDF achieved 80% sensitivity and 77% specificity for active lesions; thermography did not yield a useful cutoff.

Conclusions:

  • Laser Doppler flowmetry is a valuable noninvasive tool for assessing localized scleroderma activity in children.
  • LDF is more accurate than thermography for discriminating disease activity in this population.