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Late recurrence in children with Wilms' tumor
Münevver Büyükpamukçu1, Yavuz Köksal, Ali Varan
1Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
The Turkish Journal of Pediatrics
|October 3, 2007
Summary
Late recurrence of Wilms
Area of Science:
- Pediatric Oncology
- Clinical Research
- Cancer Recurrence
Background:
- Wilms' tumor (nephroblastoma) is a common pediatric kidney cancer.
- Late recurrence, occurring years after initial treatment, presents unique challenges.
- Understanding late recurrence patterns is crucial for improving outcomes.
Observation:
- This study retrospectively analyzed four cases of late Wilms' tumor recurrence.
- Recurrence occurred 36-96 months post-diagnosis, with stages II and IV at initial diagnosis.
- Favorable histology was noted in all cases, with initial treatment including surgery and chemotherapy.
Findings:
- Late recurrences manifested as local disease and/or lung metastasis.
- All patients exhibited regional factors like tumor spillage or lymph node involvement.
- Intensified chemotherapy regimens were used at relapse, but outcomes were poor.
Implications:
- Late Wilms' tumor recurrence is associated with a poor prognosis.
- Aggressive treatment strategies, including intensified regimens, are warranted for late recurrences.
- Further research into risk factors and optimal management of late recurrences is needed.
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