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Related Concept Videos

Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

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Related Experiment Video

Updated: Jul 11, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

Biodegradable intraprostatic doxorubicin implants.

Ronnie Ortiz1, Jessie L-S Au, Ze Lu

  • 1College of Pharmacy, Ohio State University, Columbus, OH, USA.

The AAPS Journal
|October 3, 2007
PubMed
Summary

Biodegradable doxorubicin-loaded cylinders offer a promising regional therapy for prostate cancer. These implants selectively deliver high drug concentrations directly to the prostate, causing cancer cell death without damaging surrounding tissues.

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08:38

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

Published on: August 28, 2013

Area of Science:

  • Biomedical Engineering
  • Drug Delivery Systems
  • Oncology

Background:

  • Systemic chemotherapy is ineffective for prostate-confined cancer.
  • Regional intraprostatic drug delivery presents a potential alternative treatment strategy.

Purpose of the Study:

  • To develop and evaluate biodegradable doxorubicin-loaded cylinders for intraprostatic implantation.
  • To assess the feasibility of regional intraprostatic drug therapy for prostate cancer.

Main Methods:

  • Fabrication of doxorubicin-loaded poly(lactide-co-glycolide) (PLG) cylinders with varying molecular weights and drug loadings.
  • In vitro and in vivo drug release studies in canine prostates.
  • Intraprostatic pharmacokinetic analysis and histopathological evaluation.

Main Results:

  • Biodegradable PLG cylinders were successfully prepared with controlled drug loading (10-30%) and release profiles.
  • In vivo studies demonstrated rapid drug release (approx. 80% in 48 hours) and high drug concentrations confined to the implanted lobule.
  • Histopathology confirmed localized necrotic cell death in the implanted lobule without damage to critical prostatic structures.

Conclusions:

  • Biodegradable PLG cylinders are a feasible platform for intraprostatic drug delivery.
  • This regional therapy enables selective delivery of high doxorubicin concentrations to prostate tissue.
  • This approach holds promise for treating prostate-confined cancer with improved efficacy and reduced systemic toxicity.